Vaibidang (Embelia ribes): A Potential Herbal Drug in Ayurveda with Anthelmintic Property

Authors

  • Shailja Choudhary Shuddhi Ayurveda, Jeena Sikho Lifecare Pvt. Ltd., Zirakpur 140603, Punjab, INDIA
  • Hemlata Kaurav Shuddhi Ayurveda, Jeena Sikho Lifecare Pvt. Ltd., Zirakpur 140603, Punjab, INDIA
  • Gitika Chaudhary Shuddhi Ayurveda, Jeena Sikho Lifecare Pvt. Ltd., Zirakpur 140603, Punjab, INDIA

Keywords:

Vaibidang, Embelia ribes, Anthelmintic, Rasapanchak, Ayurveda

Abstract

Embelia ribes is commonly known as vaibidang or false black pepper is a significant medicinal plant that belongs to the family Myrsinaceae. The ancient Ayurveda physician, Sushruta described that the fruit of E. ribes plant possesses anthelmintic property and is used as a tonic along with the licorice root, which prevents aging and helps in strengthening the body. The fruit of the plant is used in various ayurvedic formulations where it is used as a carminative, anthelmintic, alterative and as stimulant. Due to the overexploitation of the plant, it is considered a threatened medicinal plant. Traditionally, the plant is used as an analgesic, antibacterial, antipyretic, antifertility and anthelmintic agent. Various parts of the plant like roots, berries and leaves of E. ribes plant are used in different herbal formulations. In Ayurveda, it is used to cure skin diseases, abdominal pains, flatulence, worms, mental disorders, tumors, bronchitis, jaundice, cardio disorders and is used as a brain tonic. Embelin is considered as the major chemical constituent isolated from the Embelia ribes plant. In this review, a brief view of the plant is briefly described related to its ayurvedic and folk uses. The reported pharmacological properties of the plant are also defined.

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References

Hoareau L, DaSilva EJ. Medicinal plants: a re-emerging health aid. Electronic Journal of biotechnology. 1999 Aug;2(2):3-4.

Rai R, Nath V. Use of medicinal plants by traditional herbal healers in Central India. Indian Forester. 2005 Mar 1;131(3):463-8.

Olowokudejo JD, Kadiri AB, Travih VA. An ethnobotanical survey of herbal markets and medicinal plants in Lagos State of Nigeria.

Singh J, Singh AK, Pravesh R. Production and trade potential of some important medicinal plants: an overview. Proceedings of the 1st National Interactive Meet on Medicinal and Aromatic Plants. 2003:50.

Warrier PK, Nambiar VP, Ganapathy PM. Some important medicinal plants of the western ghats, India: a profile.2000.

Street RA, Prinsloo G. Commercially important medicinal plants of South Africa: a review. Journal of chemistry. 2013 Jan 1;2013.

Chopra RN, Nayar SL, Chopra IC. Glossary of Indian medicinal plants. New Delhi: Council of Scientific & Industrial Research; 1956.

Chopra SR, Chopra IC, Varma BS. Supplement to Glossary of Indian Medical Plants. Publication and Information Directorate; 1969.

Krishnaswamy M, Purushothaman KK. Antifertility properties of Embelia ribes:(embelin). Indian journal of experimental biology. 1980 Nov;18(11):1359-60.

Kapoor VK, Chawla AS, Kumar M, Kumar P. Anti-inflammatory agent in Indian Laboratories. Indian Drugs. 1983;30:481-8.

ELLIOTT JH, LEIBOWITZ HM. The Influence of Immunosuppressive Agents Upon Correal Wound Healing: I. Systemic Azathioprine. Archives of Ophthalmology. 1966 Sep 1;76(3):334-7.

Shankar R, Lavekar GS, Deb S, Sharma BK, Rawat MS. Distribution, conservation and folk uses of Vaibidang (Embelia ribes Burm. f.). International Journal of Biodiversity and Conservation. 2012 Oct 31;4(13):525-9.

Kirtikar KR, Basu BD. Indian medicinal plants. Indian Medicinal Plants.. 1935.

Latha C. Microwave-assisted extraction of embelin from Embelia ribes. Biotechnology letters. 2007 Feb;29(2):319-22.

Shankarmurthy K, Krishna V, Maruthi KR, Rahiman BA. Rapid adventitious organogenesis from leaf segments of Embelia ribes Burm.-a threatened medicinal plant. TAIWANIA-TAIPEI-. 2004 Sep 1; 49:194-200.

Warrier PK, Nambiar VP, Ganapathy PM. Some important medicinal plants of the western ghats, India: a profile.

Souravi K, Rajasekharan PE. Ethnopharmacological Uses of Embelia ribes Burm. F. A Review. IOSR Journal of Pharmacy and Biological Sciences. 2014 Jun;9(3):23-30.

Nadkarni K, Nadkarni AK. Indian Materia Medica, Popular Prakashan Pvt. Ltd., Bombay. 1976; 1:799.

Rao CB, Venkateswarlu V. Chemical Examination of Embelia ribes. I. Isolation of a New Constituent,“Vilangin,” Its Constitution and Synthesis. The Journal of Organic Chemistry. 1961 Nov;26(11):4529-32.

Haq K, Ali M, Siddiqui AW. New compounds from the seeds of Embelia ribes Burm. Die Pharmazie-An International Journal of Pharmaceutical Sciences. 2005 Jan 1;60(1):69-71.

Indrayan AK, Sharma S, Durgapal D, Kumar N, Kumar M. Determination of nutritive value and analysis of mineral elements for some medicinally valued plants from Uttaranchal. Current science. 2005 Oct 10:1252-5.

Lin P, Li S, Wang S, Yang Y, Shi J. A nitrogen-containing 3-alkyl-1, 4-benzoquinone and a gomphilactone derivative from Embelia ribes. Journal of natural products. 2006 Nov 27;69(11):1629-32.

Latha C. Microwave-assisted extraction of embelin from Embelia ribes. Biotechnology letters. 2007 Feb;29(2):319-22.

Haq K, Ali M, Siddiqui AW. New compounds from the seeds of Embelia ribes Burm. Die Pharmazie-An International Journal of Pharmaceutical Sciences. 2005 Jan 1;60(1):69-71.

Tambekar DH, Khante BS, Chandak BR, et al. Screening of antibacterial potentials of some medicinal plants from Melghat forest in India. Afr J Tradit Complement Altern Med. 2009;6:228–32.

McErlean CS, Moody CJ. First synthesis of N-(3-carboxylpropyl)-5-amino-2-hydroxy-3-tridecyl-1, 4-benzoquinone, an unusual quinone isolated from Embelia ribes. The Journal of organic chemistry. 2007 Dec 21;72(26):10298-301.

Raja SS, Unnikrishnan KP, Ravindran PN, Balach I. Determination of embelin in Embelia ribes and Embelia tsjeriam-conttam by HPLC. Indian journal of pharmaceutical sciences. 2005;67(6):734.

Dang PH, Nguyen HX, Nguyen NT, Le HN, Nguyen MT. α‐Glucosidase Inhibitors from the Stems of Embelia ribes. Phytotherapy Research. 2014 Nov;28(11):1632-6.

Dang PH, Nguyen NT, Nguyen HX, Nguyen LB, Le TH, Van Do TN, Van Can M, Nguyen MT. α-Glucosidase inhibitors from the leaves of Embelia ribes. Fitoterapia. 2015 Jan 1;100:201-7.

Warrier PK, Nambiar VP, Ganapathy PM. Some important medicinal plants of the western ghats, India: a profile.

Bhandari U, Kanojia R, Pillai KK. Effect of ethanolic extract of Embelia ribes on dyslipidemia in diabetic rats. International journal of experimental diabetes research. 2002 Jul 1;3(3):159-62.

Thippeswamy BS, Mahendran S, Biradar MI, Raj P, Srivastava K, Badami S, Veerapur VP. Protective effect of embelin against acetic acid induced ulcerative colitis in rats. European journal of pharmacology. 2011 Mar 1;654(1):100-5.

Shirole RL, Shirole NL, Saraf MN. Embelia ribes ameliorates lipopolysaccharide-induced acute respiratory distress syndrome. Journal of ethnopharmacology. 2015 Jun 20;168:356-63.

Ansari MN, Bhandari U. Protective effect of Embelia ribes Burm on methionine-induced hyperhomocysteinemia and oxidative stress in rat brain.

Souravi K, Rajasekharan PE. Ethnopharmacological Uses of Embelia ribes Burm. F. A Review. IOSR Journal of Pharmacy and Biological Sciences. 2014 Jun;9(3):23-30.

Asadulla S, Ramandang R. Pharmacognosy of Embelia ribes Burm f. Int J Res Pharm Chem. 2011;1(4):1236-51.

Harish GU, Danapur V, Jain R, Patell VM. Endangered medicinal plant Embelia ribes Burm. F.-a review. Pharmacognosy Journal. 2012 Jan 1;4(27):6-19.

Nadkarni K, Nadkarni AK. Indian Materia Medica, Popular Prakashan Pvt. Ltd., Bombay. 1976;1:799.

Javed IJ, Akhtar MS. Screening of Veronia anthelmintica seed and Embelia ribes fruit mixed in equal parts against gastrointestinal nematodes. Pak. J. Pharm. Sci. 1990 Jul 1;3(2):69-74.

Nadkarni AK. Indian material medica, popular prakashan pvt ltd. Bombay, India. 1982;1:1199.

Saikia AP, Ryakala VK, Sharma P, Goswami P, Bora U. Ethnobotany of medicinal plants used by Assamese people for various skin ailments and cosmetics. Journal of Ethnopharmacology. 2006 Jun 30;106(2):149-57.

Chopda MZ, Mahajan RT. Wound healing plants of Jalgaon district of Maharashtra state, India. Ethnobotanical leaflets. 2009;2009(1):1.

Goswami P, Soki D, Jaishi A, Das M, Sarma HN. Traditional healthcare practices among the Tagin tribe of Arunachal Pradesh.

Rajakumar N, Shivanna MB. Ethno-medicinal application of plants in the eastern region of Shimoga district, Karnataka, India. Journal of Ethnopharmacology. 2009 Oct 29;126(1):64-73.

Shinde, A., Gahunge, P., & Rath, S. (2018). The real concept of substitution in Ayurveda literature and adulteration the misleading concept of modern era. Journal of Ayurveda and Integrated Medical Sciences (ISSN 2456-3110), 3(3), 149-158.

Organización Mundial de la Salud, World Health Organization, Światowa Organizacja Zdrowia. WHO guidelines on good agricultural and collection practices [GACP] for medicinal plants. World Health Organization; 2003 Dec 16.

Yee SK, Chu SS, Xu YM, Choo PL. Regulatory control of Chinese proprietary medicines in Singapore. Health policy. 2005.

Menthe S, Menthe R. (2016). SUBSTITUTION AND ADULTERATION-PAST AND PRESENT.

Seethapathy, G. S., Ganesh, D., Kumar, J. U. S., Senthilkumar, U., Newmaster, S. G., Ragupathy, S., ... & Ravikanth, G. (2015). Assessing product adulteration in natural health products for laxative yielding plants, Cassia, Senna, and Chamaecrista, in Southern India using DNA barcoding. International Journal of Legal Medicine, 129(4), 693-700.

Urumarudappa, S. K. J., Gogna, N., Newmaster, S. G., Venkatarangaiah, K., Subramanyam, R., Saroja, S. G., ... & Ramanan, U. S. (2016). DNA barcoding and NMR spectroscopy-based assessment of species adulteration in the raw herbal trade of Saraca asoca (Roxb.) Willd, an important medicinal plant. International journal of legal medicine, 130(6), 1457-1470.

Kumar, J. S., Krishna, V., Seethapathy, G. S., Ganesan, R., Ravikanth, G., & Shaanker, R. U. (2018). Assessment of adulteration in raw herbal trade of important medicinal plants of India using DNA barcoding. 3 Biotech, 8(3), 1-8.

Ansari MN, Bhandari U. Antihyperhomocysteinemic Activity of an Ethanol Extract from Embelia ribes. in Albino Rats. Pharmaceutical Biology. 2008 Jan 1;46(4):283-7.

Chitra M, Shyamala Devi CS, Sukumar E. Antibacterial activity of embelin. Fitoterapia. 2003 Jun 1;74(4):401-3.

Gajjar UH, Khambholja KM, Patel RK. Comparison of anti microbial activity of Bhallataka Rasayana and its ingredient. International Journal of PharmTech Research. 2009;1(4):1594-7.

Jalalpure SS, Alagawadi KR, Mahajanashetti CS, Shah BN, Singh V, Patil JK. In vitro anthelmintic property of various seed oils against Pheritima posthuma. Indian journal of pharmaceutical sciences. 2007;69(1):158.

Tambekar DH, Khante BS, Chandak BR, Titare AS, Boralkar SS, Aghadte SN. Screening of antibacterial potentials of some medicinal plants from Melghat forest in India. African Journal of Traditional, Complementary and Alternative Medicines. 2009;6(3).

Hördegen P, Cabaret J, Hertzberg H, Langhans W, Maurer V. In vitro screening of six anthelmintic plant products against larval Haemonchus contortus with a modified methyl-thiazolyl-tetrazolium reduction assay. Journal of Ethnopharmacology. 2006 Nov 3;108(1):85-9.

Javed IJ, Akhtar MS. Screening of Veronia anthelmintica seed and Embelia ribes fruit mixed in equal parts against gastrointestinal nematodes. Pak. J. Pharm. Sci. 1990 Jul 1;3(2):69-74.

Gupta OP, Ali MM, BJ RG, Atal CK. Some pharmacological investigations of embelin and its semisynthetic derivatives. Indian journal of physiology and pharmacology. 1977 Jan 1;21(1):31-9.

Atal CK, Siddiqui MA, Zutshi U, Amla V, Johri RK, Rao PG, Kour S. Non-narcotic orally effective, centrally acting analgesic from an Ayurvedic drug. Journal of ethnopharmacology. 1984 Aug 1;11(3):309-17.

Zutshi U, Johri RK, Atal CK. Possible interaction of potassium embelate, a putative analgesic agent, with opiate receptors. Indian journal of experimental biology. 1989 Jul 1;27(7):656-7.

Bhandari U, Ansari MN. Antihyperglycaemic activity of aqueous extract of Embelia ribes Burm in streptozotocin-induced diabetic rats.

Bhandari U, Jain N, Pillai KK. Further studies on antioxidant potential and protection of pancreatic β-cells by Embelia ribes in experimental diabetes. Experimental Diabetes Research. 2007 Jan 1;2007.

Joshi R, Kamat JP, Mukherjee T. Free radical scavenging reactions and antioxidant activity of embelin: biochemical and pulse radiolytic studies. Chemico-biological interactions. 2007 Apr 25;167(2):125-34.

Bhandari U, Jain N, Ansari MN, Pillai KK. Beneficial effect of Embelia ribes ethanolic extract on blood pressure and glycosylated hemoglobin in streptozotocin-induced diabetes in rats. Fitoterapia. 2008 Jul 1;79(5):351-5.

Nazam Ansari M, Bhandari U, Islam F, Tripathi CD. Evaluation of antioxidant and neuroprotective effect of ethanolic extract of Embelia ribes Burm in focal cerebral ischemia/reperfusion‐induced oxidative stress in rats. Fundamental & clinical pharmacology. 2008 Jun;22(3):305-14.

Swamy HK, Krishna V, Shankarmurthy K, Rahiman BA, Mankani KL, Mahadevan KM, Harish BG, Naika HR. Wound healing activity of embelin isolated from the ethanol extract of leaves of Embelia ribes Burm. Journal of ethnopharmacology. 2007 Feb 12;109(3):529-34.

Chauhan S, Agrawal S, Mathur R, Gupta RK. Phosphatase activity in testis and prostate of rats treated with embelin and Vinca rosea extract. Experientia. 1979 Sep;35(9):1183-5.

Prakash AO, Mathur R. Biochemical changes in the rat uterine tissue following Embelia ribes burm. extracts. Indian Journal of Pharmacology. 1979 Apr 1;11(2):127.

Kholkute SD, SD K, MB K. Antifertility effects of Embelia ribes Burm.1978.

Chitra M, Sukumar E, Suja V, Devi S. Antitumor, anti-inflammatory and analgesic property of embelin, a plant product. Chemotherapy. 1994;40(2):109-13.

Seshadri C, Sitaram R, Pillai SR, Venkataraghavan S. Effect of aqueous and alcoholic extract of the berries of Embelia ribes on male reprocuctive organs in adult rats. A preliminary study. Bull Med Ethnobot Res. 1980;1:272-80.

Low G, Rogers LJ, Brumley SP, Ehrlich D. Visual deficits and retinotoxicity caused by the naturally occurring anthelmintics, Embelia ribes and Hagenia abyssinica. Toxicology and applied pharmacology. 1985 Nov 1;81(2):220-30.

Chaudhury MR, Chandrasekaran R, Mishra S. Embryotoxicity and teratogenicity studies of an ayurvedic contraceptive—pippaliyadi vati. Journal of ethnopharmacology. 2001 Feb 1;74(2):189-93.

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Published

2021-03-31

How to Cite

Shailja Choudhary, Hemlata Kaurav, & Gitika Chaudhary. (2021). Vaibidang (Embelia ribes): A Potential Herbal Drug in Ayurveda with Anthelmintic Property. International Journal for Research in Applied Sciences and Biotechnology, 8(2), 237–243. Retrieved from https://ijrasb.com/index.php/ijrasb/article/view/75

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