Daruharidra (Berberis aristata): Review based upon its Ayurvedic Properties

Authors

  • Shailja Choudhary Research and Development Department, Shuddhi Ayurveda, Jeena Sikho Lifecare Pvt. Ltd., Zirakpur 140603, Punjab, INDIA.
  • Hemlata Kaurav Research and Development Department, Shuddhi Ayurveda, Jeena Sikho Lifecare Pvt. Ltd., Zirakpur 140603, Punjab, INDIA.
  • Madhusudan S. Research and Development Department, Shuddhi Ayurveda, Jeena Sikho Lifecare Pvt. Ltd., Zirakpur 140603, Punjab, INDIA.
  • Gitika Chaudhary Research and Development Department, Shuddhi Ayurveda, Jeena Sikho Lifecare Pvt. Ltd., Zirakpur 140603, Punjab, INDIA.

Keywords:

Daruharidra, Antidiabetic, Rasapanchak, Ayurveda, Berberine

Abstract

Berberis aristata is also known as daruharidra which is a famous plant and used in various medicinal systems like Ayurveda, Homeopathy, Unani, Chinese and Allopathy for a very long time. It is a spinous, hard, yellowish herb belongs to the family Berberidaceae. The plant is distributed in sub- Himalayan regions, Sri Lanka, Bhutan and hilly areas of Nepal. It played a significant role as an herbal remedy for more than 2500 years. It was used by ancient Egyptians to anticipate plague disease. European herbalists used this plant to treat liver and gall bladder disorders during the early middle ages. Russian therapists used B. aristata plant to cure inflammation, high blood pressure and abnormal menstrual cycle. It is used as a bitter tonic, stomachic, cholagogue, antiperiodic and alternative by American Indians to cure intermittent fever, neuralgia and menorrhagia. In the traditional medicinal system, the plant is used to treat skin diseases, menorrhagia, diarrhea, eye problem inflammation and wound healing. Fruit of the plant is a rich source of Vitamin C. The main active constituent of the plant is Berberine found mainly in its roots.  The most important formulation of this plant is 'Rashut' that is acts as a tonic as well as blood purifier and also used to treat ulcer and ophthalmic diseases. Reported clinical and experimental studies showed that the plant possesses various pharmacological properties like antimicrobial, anti-inflammatory, analgesic, antipyretic, hepatoprotective, immunomodulatory and cardiotonic activity. 

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References

Ved, D. K., & Goraya, G. S. (2007). Demand and supply of medicinal plants in India. NMPB, New Delhi & FRLHT, Bangalore, India, 18.

Chakravarty, S., Ghosh, S. K., Suresh, C. P., Dey, A. N., & Shukla, G. (2012). Deforestation: causes, effects and control strategies. Global perspectives on sustainable forest management, 1, 1-26.

Safarzadeh, E., Shotorbani, S. S., & Baradaran, B. (2014). Herbal medicine as inducers of apoptosis in cancer treatment. Advanced pharmaceutical bulletin, 4(Suppl 1), 421.

Sen, S., & Chakraborty, R. (2017). Revival, modernization and integration of Indian traditional herbal medicine in clinical practice: Importance, challenges and future. Journal of traditional and complementary medicine, 7(2), 234-244.

Ramawat, K. G., & Goyal, S. (2008). The Indian herbal drugs scenario in global perspectives. Bioactive molecules and medicinal plants, 325-347.

Watt, G. (1893). A dictionary of the economic products of India (Vol. 6). Superintendent of Government Printing.

Patel Pineshkumar S, Gajera V, Lambole V, Shah DP. (2019). PHYTOCHEMISTRY AND PHARMACOLOGICAL ACTIVITIES OF BERBERIS ARISTATA: AN OVERVIEW.

Ramawat, K. G., & Goyal, S. (2008). The Indian herbal drugs scenario in global perspectives. Bioactive molecules and medicinal plants, 325-347.

Vassou SL, Nithaniyal S, Raju B, Parani M. Creation of reference DNA barcode library and authentication of medicinal plant raw drugs used in Ayurvedic medicine. BMC complementary and alternative medicine. 2016 Jul;16(1):9-15.

Shinwari, Z. K. (2010). Medicinal plants research in Pakistan. Journal of medicinal plants research, 4(3), 161-176.

Chander, V., Aswal, J. S., Dobhal, R., & Uniyal, D. P. (2017). A review on Pharmacological potential of Berberine; an active component of Himalayan Berberis aristata. J Phytopharmacol, 6(1), 53-58.

Murad, H. M., Abdulameer, S. A., Aljuboory, D. S. A., Neamah, D. A., & Maktouf, A. H. (2020). Defensive Effects of Breberine against Cypermethrin Induced Male Reproductive System Toxicity in Rabbits. Systematic Reviews in Pharmacy, 11(9), 841-846.

Joshi, A. R., & Joshi, K. (2007). Ethnomedicinal plants used against skin diseases in some villages of Kali Gandaki, Bagmati and Tadi Likhu watersheds of Nepal. Ethnobotanical leaflets, 2007(1), 27.

Dutta, N. K., & Panse, M. V. (1962). Usefulness of Berberine (an Alkaloid from Berberis aristata) in the Treatment of Cholera (Experimental). Indian Journal of Medical Research, 50(5), 732-6.

Lahiri, S. C., & Dutta, N. K. (1967). Berberine and chloramphenicol in the treatment of cholera and severe diarrhoea. Journal of the Indian Medical Association, 48(1), 1-11.

Shahid, M., Rahim, T., Shahzad, A., Latif, T. A., Fatma, T., Rashid, M., ... & Mustafa, S. (2009). Ethnobotanical studies on Berberis aristata DC. root extracts. African Journal of Biotechnology, 8(4).

Muralidhar, C. V., & Kiran, K. K. (2018) A COMPREHENSIVE REVIEW OF DARUHARIDRA (Berberis Aristata).

Komal, S., Ranjan, B., Neelam, C., Birendra, S., & Kumar, S. N. (2011). Berberis aristata: A review. Int J Res Ayurveda Pharm, 2(2), 383-388.

Chaudhari, V. M., & Kokate, K. K. A COMPREHENSIVE REVIEW OF DARUHARIDRA. International Journal of Research in Ayurveda and Medical Sciences, 1, 153-159..

Khory, R. N., & Katrak, N. N. (1903). Materia Medica of India and their therapeutics. Caxton Works.

Parmar, C., & Kaushal, M. K. (1982). Berberis aristata: Wild fruits. Kalyani Publishing Ludhiana, 10-14.

Kala, C. P., Dhyani, P. P., & Sajwan, B. S. (2006). Developing the medicinal plants sector in northern India: challenges and opportunities. Journal of Ethnobiology and Ethnomedicine, 2(1), 1-15.

Malairajan, P., Gopalakrishnan, G., Narasimhan, S., & Veni, K. J. K. (2006). Analgesic activity of some Indian medicinal plants. Journal of ethnopharmacology, 106(3), 425-428.

Rajasekaran, A., & Pant, J. (2008). The genus Berberis linn.: A review. Pharmacognosy Review, 2(4).

Rajasekaran, A., & Kumar, N. (2009). Rasont–A traditional crude drug prepared from Berberis sp and its uses.

Chandra, H., Patel, D., Kumari, P., Jangwan, J. S., & Yadav, S. (2019). Phyto-mediated synthesis of zinc oxide nanoparticles of Berberis aristata: Characterization, antioxidant activity and antibacterial activity with special reference to urinary tract pathogens. Materials Science and Engineering: C, 102, 212-220.

Bhardwaj, D., & Kaushik, N. (2012). Phytochemical and pharmacological studies in genus Berberis. Phytochemistry reviews, 11(4), 523-542.

Chakravarti, K. K., Dhar, D. C., & Siddiqui, S. (1950). Alkaloidal consistuents of the bark of Berberis aristata. Journal of Scientific and Industrial Research, (7), 161-4.

Blasko, G., Murugesan, N., Freyer, A. J., Shamma, M., & Ansari, A. A. (1982). Karachine: an unusual protoberberine alkaloid. Journal of the American Chemical Society, 104(7), 2039-2041.

RAHMAN, A., & Ansari, A. A. (2011). Alkaloids of Berberis aristata-isolation of aromoline and oxyberberine. Journal of The Chemical Society of Pakistan, 5(4), 283.

Saied, S., & Batool, S. (2007). Shaista Naz, Phytochemical studies of Berberis aristata, J. Basic Appl. Sci, 3(1), 1-3.

Blasko, G., ANSARI, A. A., & RAHMAN, A. U. (1982). Taxilamine, a pseudobenzylisoquinoline alkaloid.

Sivakumar, R., & KAMACHANDRAN NAIR, A. G. (1991). Polyphenolic constituents of the flowers of Berberis aristata. Journal of the Indian Chemical Society, 68(9), 531-532.

Sivakumar, R., & KAMACHANDRAN NAIR, A. G. (1991). Polyphenolic constituents of the flowers of Berberis aristata. Journal of the Indian Chemical Society, 68(9), 531-532.

Katiyar, D., Singh, R. K., Singh, S., Singh, D., & Singh, V. (2011). Isolation and characterization of n-docosane from heartwood of Berberis aristata. International Journal of Pharmaceutical Sciences and Research, 2(2), 331.

Meena, A. K., Bansal, P., Kumar, S., Rao, M. M., & Garg, V. K. (2010). Estimation of heavy metals in commonly used medicinal plants: a market basket survey. Environmental monitoring and assessment, 170(1), 657-660..

Chakravarti, K. K., Dhar, D. C., & Siddiqui, S. (1950). Alkaloidal consistuents of the bark of Berberis aristata. Journal of Scientific and Industrial Research, (7), 161-4.

Andola, H. C., Gaira, K. S., Rawal, R. S., Rawat, M. S. M., & Bhatt, I. D. (2010). Habitat‐Dependent Variations in Berberine Content of Berberis asiatica Roxb. ex. DC. in Kumaon, Western Himalaya. Chemistry & biodiversity, 7(2), 415-420.

Sharma, P. C., Yelne, M. B., Dennis, T. J., Joshi, A., & Billore, K. V. (2000). Database on medicinal plants used in Ayurveda.

Joshi, A. R., & Joshi, K. (2007). Ethnomedicinal plants used against skin diseases in some villages of Kali Gandaki, Bagmati and Tadi Likhu watersheds of Nepal. Ethnobotanical leaflets, 2007(1), 27.

Saraf, G., Mitra, A., Kumar, D., Mukherjee, S., & Basu, A. (2010). Role of nonconventional remedies in rural India. International Journal of Pharmacy and Life Sciences (IJPLS), 1(3), 141-159.

Yogesh, H. S., Chandrashekhar, V. M., Katti, H. R., Ganapaty, S., Raghavendra, H. L., Gowda, G. K., & Goplakhrishna, B. (2011). Anti-osteoporotic activity of aqueous-methanol extract of Berberis aristata in ovariectomized rats. Journal of ethnopharmacology, 134(2), 334-338.

Shahid, M., Rahim, T., Shahzad, A., Latif, T. A., Fatma, T., Rashid, M., ... & Mustafa, S. (2009). Ethnobotanical studies on Berberis aristata DC. root extracts. African Journal of Biotechnology, 8(4).

Duke, J., & Bogenschutz, M. J. (1994). Dr. Duke's phytochemical and ethnobotanical databases (pp. 1-8). USDA, Agricultural Research Service.

Meena, A. K., Bansal, P., & Kumar, S. (2009). Plants-herbal wealth as a potential source of ayurvedic drugs. Asian Journal of Traditional Medicines, 4(4), 152-170.

Sati, S. C., & Joshi, S. (2011). Aspects of antifungal potential of ethnobotanically known medicinal plants. Research Journal of Medicinal Plants, 5(4), 377-391.

Phondani, P. C., Maikhuri, R. K., Rawat, L. S., Farooquee, N. A., Kala, C. P., Vishvakarma, S. R., ... & Saxena, K. G. (2010). Ethnobotanical uses of plants among the Bhotiya tribal communities of Niti Valley in Central Himalaya, India.

Sharma, P. K., Chauhan, N. S., & Lal, B. (2005). Studies on plant associated indigenous knowledge among Malanis of Kullu district, Himachal Pradesh. Indian Journal of Traditonal Knowledege, 4(4), 403-408.

Tiwari, J. K., Ballabha, R., & Tiwari, P. (2010). Ethnopaediatrics in Garhwal Himalaya, Uttarakhand, India (Psychomedicine and Medicine). New York Sci. J, 3(4), 123-126.

Acharya, K. P., & Rokaya, M. B. (2005). Ethnobotanical survey of medicinal plants traded in the streets of Kathmandu valley. Scientific World, 3(3), 44-48.

Kunwar, R. M., & Adhikari, N. (2005). Ethnomedicine of Dolpa district, Nepal: the plants, their vernacular names and uses. Lyonia, 8(1), 43-49.

Chhetri, D. R., Parajuli, P., & Subba, G. C. (2005). Antidiabetic plants used by Sikkim and Darjeeling Himalayan tribes, India. Journal of Ethnopharmacology, 99(2), 199-202.

Chander, V., Aswal, J. S., Dobhal, R., & Uniyal, D. P. (2017). A review on Pharmacological potential of Berberine; an active component of Himalayan Berberis aristata. J Phytopharmacol, 6(1), 53-58.

Komal, S., Ranjan, B., Neelam, C., Birendra, S., & Kumar, S. N. (2011). Berberis aristata: A review. Int J Res Ayurveda Pharm, 2(2), 383-388.

Parmar, C., & Kaushal, M. K. (1982). Berberis aristata: Wild fruits. Kalyani Publishing Ludhiana, 10-14.

Rajasekaran, A., & Pant, J. (2008). The genus Berberis linn.: A review. Pharmacognosy Review, 2(4).

Potdar, D., Hirwani, R. R., & Dhulap, S. (2012). Phyto-chemical and pharmacological applications of Berberis aristata. Fitoterapia, 83(5), 817-830.

Kasture, V. S., & Gharate, M. K. (2011). SIMPLE AND RAPID SCHEME OF STANDARDIZATION OF LOHASAVA. international Journal of Ayurvedic and Herbal Medicine, 1(03).

Pandey, G. (2004). Dravyaguna vijnana. Part III, Chowkhamba Krishnadas Academy, Varanasi (Reprint), 852.

Shinde, A., Gahunge, P., & Rath, S. (2018). The real concept of substitution in Ayurveda literature and adulteration the misleading concept of modern era. Journal of Ayurveda and Integrated Medical Sciences (ISSN 2456-3110), 3(3), 149-158.

Menthe S, Menthe R. (2016). SUBSTITUTION AND ADULTERATION-PAST AND PRESENT.

Seethapathy, G. S., Ganesh, D., Kumar, J. U. S., Senthilkumar, U., Newmaster, S. G., Ragupathy, S., ... & Ravikanth, G. (2015). Assessing product adulteration in natural health products for laxative yielding plants, Cassia, Senna, and Chamaecrista, in Southern India using DNA barcoding. International Journal of Legal Medicine, 129(4), 693-700.

Urumarudappa, S. K. J., Gogna, N., Newmaster, S. G., Venkatarangaiah, K., Subramanyam, R., Saroja, S. G., ... & Ramanan, U. S. (2016). DNA barcoding and NMR spectroscopy-based assessment of species adulteration in the raw herbal trade of Saraca asoca (Roxb.) Willd, an important medicinal plant. International journal of legal medicine, 130(6), 1457-1470.

Kumar, J. S., Krishna, V., Seethapathy, G. S., Ganesan, R., Ravikanth, G., & Shaanker, R. U. (2018). Assessment of adulteration in raw herbal trade of important medicinal plants of India using DNA barcoding. 3 Biotech, 8(3), 1-8.

Sohni, Y. R., & Bhatt, R. M. (1996). Activity of a crude extract formulation in experimental hepatic amoebiasis and in immunomodulation studies. Journal of ethnopharmacology, 54(2-3), 119-124.

Gilani, A. U., & Janbaz, K. H. (1995). Studies on protective effect of Cyperus scariosus extract on acetaminophen and CCl4-induced hepatotoxicity. General pharmacology, 26(3), 627-631.

Tsai, P. L., & Tsai, T. H. (2004). Hepatobiliary excretion of berberine. Drug Metabolism and Disposition, 32(4), 405-412.

Feng, Y., Cheung, K. F., Wang, N., Liu, P., Nagamatsu, T., & Tong, Y. (2009). Chinese medicines as a resource for liver fibrosis treatment. Chinese medicine, 4(1), 1-11.

Chaudhari, V. M., & Kokate, K. K. A COMPREHENSIVE REVIEW OF DARUHARIDRA. International Journal of Research in Ayurveda and Medical Sciences, 1, 153-159.

Shailasree, S., Ruma, K., Kini, K. R., Niranjana, S. R., & Prakash, H. S. (2012). Potential anti-inflammatory bioactives from medicinal plants of Western Ghats, India. Pharmacogn Commun, 2(2), 71-7.

Chang, W., Chen, L., & Hatch, G. M. (2015). Berberine as a therapy for type 2 diabetes and its complications: from mechanism of action to clinical studies. Biochemistry and cell biology, 93(5), 479-486.

Vuddanda, P. R., Chakraborty, S., & Singh, S. (2010). Berberine: a potential phytochemical with multispectrum therapeutic activities. Expert opinion on investigational drugs, 19(10), 1297-1307.

Singh, M., Srivastava, S., & Rawat, A. K. S. (2007). Antimicrobial activities of Indian Berberis species. Fitoterapia, 78(7-8), 574-576.

Malik, F., Mirza, T., Riaz, H., Hameed, A., & Hussain, S. (2010). Biological screening of seventeen medicinal plants used in the traditional systems of medicine in Pakistan for antimicrobial activities. African Journal of Pharmacy and Pharmacology, 4(6), 335-340.

Padma, D., Pooja, G., & Ravi, S. (2009). In vitro and in vivo efficacy of a herbal formulation against skin infections. Journal of Pure and Applied Microbiology, 3(1), 199-204.

Sharma, R. S., Mishra, V., Singh, R., Seth, N., & Babu, C. R. (2008). Antifungal activity of some Himalayan medicinal plants and cultivated ornamental species. Fitoterapia, 79(7-8), 589-591.

Joshi, P. V., Shirkhedkar, A. A., Prakash, K., & Maheshwari, V. L. (2011). Antidiarrheal activity, chemical and toxicity profile of Berberis aristata. Pharmaceutical biology, 49(1), 94-100.

Sack, R. B., & Froehlich, J. L. (1982). Berberine inhibits intestinal secretory response of Vibrio cholerae and Escherichia coli enterotoxins. Infection and immunity, 35(2), 471-475.

Sabir, M., Akhter, M. H., & Bhide, N. K. (1977). Antagonism of cholera toxin by berberine in the gastrointestinal tract of adult rats. Indian journal of medical research, 65(3), 305-313.

Upwar, N., Patel, R., Waseem, N., & Mahobia, N. K. (2010). Pharmacognostic Evaluation of stem of Berberis aristata DC. Pharmacognosy Journal, 2(17), 5-9.

Goli, D. (2007). Anti-diabetic activity of stem bark of Berberis aristata DC in alloxan induced diabetic rats (Doctoral dissertation, RGUHS).

Wasana, K. G. P., Attanayake, A. P., Jayatilaka, K. A. P. W., & Weerarathna, T. P. (2020). Natural drug leads as novel DPP-IV inhibitors targeting the management of type 2 diabetes mellitus. Journal of Complementary Medicine Research, 11(1), 43-53.

Das, S., Das, M. K., Mazumder, P. M., Das, S., & Basu, S. P. (2009). Cytotoxic activity of methanolic extract of Berberis aristata DC on colon cancer. Global Journal of Pharmacology, 3(3), 137-140.

Mazumder, P. M., Das, S., Das, S., & Das, M. K. (2010). Cytotoxic activity of methanolic extracts of Berberis aristata DC and Hemidesmus indicus R. Br. MCF7 Cell Line. Journal of Current Pharmaceutical Research 2010; 1: 12, 15.

Anis, K. V., Rajeshkumar, N. V., & Kuttan, R. (2001). Inhibition of chemical carcinogenesis by berberine in rats and mice. Journal of Pharmacy and Pharmacology, 53(5), 763-768.

Anis, K. V., Rajeshkumar, N. V., & Kuttan, R. (2001). Inhibition of chemical carcinogenesis by berberine in rats and mice. Journal of Pharmacy and Pharmacology, 53(5), 763-768.

Patel, J., Aneja, K., & Tiwari, R. (2010). A review on bioavailability and bioequivalence trials and its necessity. Int J Pharmacy Pharm Sci, 2(3), 1-8.

Tripathi, Y. B., & Shukla, S. D. (1996). Berberis aristata inhibits PAF induced aggregation of rabbit platelets. Phytotherapy Research, 10(7), 628-630.

Shah, B. H., Nawaz, Z., Saeed, S. A., & Gilani, A. H. (1998). Agonist‐dependent differential effects of berberine in human platelet aggregation. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 12(S1), S60-S62.

Gilani, A. H., Janbaz, K. H., Aziz, N., Herzig, M. J., Kazmi, M. M., Choudhary, M. I., & Herzig, J. W. (1999). Possible mechanism of selective inotropic activity of the n-butanolic fraction from Berberis aristata fruit. General Pharmacology: The Vascular System, 33(5), 407-414.

Razzaq, F. A., Khan, R. A., Feroz, Z., & Afroz, S. (2011). Effect of Berberis aristata on lipid profile and coagulation parameters. African Journal of Pharmacy and Pharmacology, 5(7), 943-947.

Ahmed, K. M., Khan, M., & Shivananda, B. (2009). Cardiovascular diseases and role of medicinal plants as a re-emerging health aid. Pharmacognosy Reviews, 3(5), 8.

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Published

2021-03-31

How to Cite

Choudhary, S. ., Kaurav, H. ., S., M. ., & Chaudhary, G. . (2021). Daruharidra (Berberis aristata): Review based upon its Ayurvedic Properties. International Journal for Research in Applied Sciences and Biotechnology, 8(2), 98–106. Retrieved from https://ijrasb.com/index.php/ijrasb/article/view/50

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