Synthesis of Pharmaceutically Important Isoxazoles
Keywords:
Naphthofuran, Pyridine, Chalcones, IsoxazolesAbstract
2-acetylnaphtho [2,1-b] furan has been synthesized by literature (Stoermer & Schaffer) method. It is then converted in to a series of Chalcones on treatment with p-substituted aromatic aldehyde. (1a-f) by Claisen-Schmidt condensation. These chalcones on reaction with Br2 in presence of methanol and glacial acetic acid gave their dibromo derivative (2a-f). This product reacts with hydroxylamine hydrochloride in pyridine and methanol respectively to get isomeric isoxazoles (3a-f) and (4a-f). The antimicrobial screening showed that many of these synthesised compounds have good activity against bacteria and fungi.
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