Correlation Between Serum Inhibin and FSH Levels in Women with Different Reproductive Disorders
Keywords:
Inhibin-B, amenorrhea, polycystic ovaryAbstract
Inhibin was first identified as a gonadal factor that inhibits FSH (inhibin- B) and LH (inhibin- A) synthesis at the pituitary which proved by tissue culture. During the later years, the role of FSH was defined and the role of inhibin to control FSH biosynthesis and secretion was cleard. Inhibin is a member of the transforming growth factor beta (TGFβ) superfamily which includes molecules like activin . Inhibin is similar to activin in structure with both having β- subunits . Inhibin -B blocks the ability of activin to induce FSH secretion by blocking the activin-receptor interaction. In the female the ovary is the major source of inhibin synthesis , the granulosa cells in developing follicles , or lutein cells in the corpus luteum are the major source of inhibin. The study aimed to measure the level of inhibin hormone in normal and abnormal adult women, study the changes in inhibin hormone level and to explain the relationship between these changes and different pathological conditions. The experimental groups used consists of 80 women aged between 20-52 years old, which divided into: women with normal menstrual cycle, women with irregular menses, women with polycystic ovary and women with amenorrhea. The study demonstrated that inhibin- B concentrations negatively correlated with FSH concentrations in normal and abnormal patients .However in infertile patients, inhibin– B was significantly decreased and FSH was significantly increased . While in normal patients the result was found to be opposite of abnormal patients . These results suggest that the physiologically important hormone that exerts tonic negative feedback upon FSH secretion is inhibin- B.
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