Study Correlation between Some Immune Markers in Patients with Lichen Planus: Review Article
Keywords:
inflammatory disease, immune marker, patients, lichen planus, p53Abstract
Lichen planus is an autoimmune disorder that primarily affects the body's skin and multiple mucous membranes. In multicellular species, protein 53 and syndecan-1protein play an significant role since they control the cell cycle and thus play a major role in tumor suppression and cancer prevention. The p53 gene was therefore identified as a "genome protector," referring to its role in preserving the integrity of genetic information by preventing gene mutations. The purpose of this analysis was to study the association between certain immune markers in lichen planus patients. The aim of this study: Study correlation between some immune markers in patients with lichen planus.
Methods: 'Thirty formalin-fixed, paraffin-embedded tissue pieces, diagnosed as Oral Lichen planus (OLP), were included in the sample of this report.
Results: Evaluation of P53 Immunohistochemistry and Evaluation of syndecan-1protein Immunohistochemistry
Conclusion: The marker p53 expression is high in the patient with Lichen Planus while the second studed markersyndecan-1 protein is less than marker p53.
Downloads
References
Ghaderi R, Makhmalbaf Z. The relationship between lichen planus and hepatitis C in Birjand, Iran. Shiraz E-med J. 2007;8:72–9.
Beaird LM, Kahloon N, Franco J, et al. Incidence of hepatitis c in lichen planus. J Am AcadDermatol. 2001;44:311–1.
Tovaru S, Tovaru M, Costache M, et al. MedicinasipatologieOralavolumul I Q Med Publishing 2008
Nagao Y, Myoken Y, Katayama K, et al. Epidemiological survey of oral lichen planus among HCV infected inhabitantsin a town in Hiroshima Prefecturrein Japan from 2000 to 2003. Oncol Rep. 2007;18:1177–81.
Kirtak N, Inaloz HS, Ozgoztasi O, et al. The prevalence of hepatitis Cvirusinfectionin patients with lichen planus in Gazinateq region of Turkey. Eur J Epidemiol. 2000;16:1159–61.
Karaverioglu D, Koytak ES, Bazkaya H, et al. Lichen planus and HCV infection in Turkish patients. Turk J Gastroenterol. 2004;15:133–6.
Harman M, Akdeniz S, Dursun M, et al. Lichen planus and hepatitis C virus infection: an epidemiologic study. Int J clinPract. 2004;58:1118–9.
Denli YG, Durdu M, Karakas M. Diabetes and hepatitis frequency in 140 lichen planus cases in Cukurova region. J Dermatol. 2004;31:293–8.
Gimenez-Garcia R, Perez-Castrillon JL. Lichen planus and hepatitis C virus infection. J EurAcadDermatolVenerol. 2003;17:291–5.
Giuliani M, Lajolo C, Miani CM, et al. Hepatitis C virus chronic infection and oral lichen planus: an italian case control study. Eur. J GastroenterolHepatol. 2007;19:647–52.
Lodi G, Giuliani M, Majorana A, et al. Lichen planusand hepatitis C virus: a multicentre study of patients with oral lesions and a systematic review. Br. J Dermatol. 2004;151:1172–81.
Mouelhi L, Debbeche R, Sfar I, et al. Auto-immune serological disorders in chronic viral C hepatitis: prevalence and clinical significance. Tunis Med. 2008;86:777–81.
Ko HM1, Hernandez-Prera JC, Zhu H, et al. Morphologic Features of Extrahepatic Manifestations of Hepatitis C Virus Infection Clinical and Developmental Immunology. 2012;2012:740138–740138.
Ibrahim HA, Baddour MM, Morsi MG, et al. Should we routinely check for hepatitis B and C in patients with lichen planus or cutaneous vasculitis? East Mediterr Health J. 1999;5:71–8.
Gheorghe L, Csiki IE, Iacob S, et al. The prevalence and risk factors of hepatitis C virus infection in adult population in Romania: a nationwide survey 2006-2008. J Gastrointestin Liver Dis. 2010;19:373–9.
Molnar GB, Cocean S, Jebeleanu L, et al. Evaluareaepidemiologicaainfectieianamnestice cu virus hepatitic C la populatia din 11 judete ale Romaniei. Rom J Infect Dis. 2005;8:3–7.
MohdHanafiah K, Groeger J, Flaxman AD. Global epidemiology of hepatitis C virus infection: New estimates of age-specific antibody to HCV seroprevalence. Hepatology. 2013;57:1333–42.
Sugerman PB, Savage NW, Walsh LJ, et al. The pathogenesis of oral lichen planus. Crit Rev Oral Biol Med. 2002;13:350–65.
Tovaru S. Incidence of oral lesions in a selected hospital populations Poster 11 thBiennal Congress of EAOM Athens 2012
Scully C, Carozzo M. Oral mucosa disease-lichen planus. Br J Oral Maxilofac Surg. 2008;46:15–21.
Roopashree MR, Gondhalekar RV, Shashikanth MC, George J, Thippeswamy SH, Shukla A. Pathogenesis of oral lichen planus--a review. J Oral Pathol Med 2010;39:729-34.
Sagari S, Sanadhya S, Doddamani M, Rajput R. Molecular markers in oral lichen planus: A systematic review. J Oral MaxillofacPathol 2016;20:115-21.
Hadzi-Mihailovic M, Cakic S, Jankovic S, Raybaud H, Nedeljkovic N, Jankovic L. Ki-67 expression in oral lichen planus. J BUON 2012;17:132-7.
Irani S, Esfahani AM, Ghorbani A. Dysplastic change rate in cases of oral lichen planus: A retrospective study of 112 cases in an Iranian population. J Oral MaxillofacPathol 2016;20:395-99.
Oliveira Alves M, Balducci I, RodarteCarvalho Y, Cabral L, Nunes F, Almeida J. Evaluation of the expression of p53, MDM2, and SUMO-1 in oral lichen planus. Oral Dis 2013;19:775-80.
Vousden KH. p53:death star. Cell 2000;103:691-4.
de Oliveira MG, Ramalho LM, Gaião L, Pozza DH, de Mello RA. Retinoblastoma and p53 protein expression in pre-malignant oral lesions and oral squamous cell carcinoma. Mol Med Rep 2012;6:163-6.
Sankari SL, Babu NA, Rajesh E, Kasthuri M. Apoptosis in immune-mediated diseases. J Pharm BioalliedSci 2015;7(Suppl 1):S200-2.
Dheeb B. I., (2015). Antifungal Activity of Alkaloids and Phenols Compounds extracted from black pepper Piper nigrum against some pathogenic fungi Jornal of Biotechnology Research Center (2015) 9 , 46-54.h.
Lin T, Lin Y. p53 switches off pluripotency on differentiation. Stem Cell Res Ther 2017; 28:8.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
editor@ijrasb.com 