Treatment of Alzheimer Disease with Anti-Diabetic Medications
DOI:
https://doi.org/10.31033/ijrasb.9.3.21Keywords:
Alzheimer's disease, Type 2 DM, Neuro-protective, Insulin dependentAbstract
AD and T2DM are widespread among elderly globally. Epidemiological studies suggest T2DM causes AD. AD brains have reduced glucose uptake, indicating insulin resistance. A plaques and tau tangles are AD pathology. Insulin resistance in T2DM directly exacerbates A and tau pathologies, while synaptic dysfunction, inflammation, and autophagy impairments are common to both illnesses and indirectly impact A and tau neuronal activity. Understanding how these diseases are linked can help find novel Alzheimer's drug targets.
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