Forecasting the Protocol for Microwave Radiation Availed Forced Degradation of the Drug Molecules
Keywords:
Drug Stability, Forced Degradation, Protocol, FactorsAbstract
The Forced degradation and stability testing involve the foremost time portion in researching the chemistry of the molecules. To obtain a green and fast technique for forced degradation study of the drug molecules, microwave radiation is adopted for the studies in the recent scenario. The drug development life cycle may be a long process that additionally involves ample efforts within the testing of the chemical stability of the drug molecules and potential impurity and degradation product of the drug before it comes within the sort of stable formulation. This shows the vital development within the forced degradation methodology by this innovative approach. As the approach is new it requires a methodical protocol, the paper presents suitable factorial setups for the described application.
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N Patel P. & J Mehta P. (2017). Impact of Microwave Assisted Heating on Hydrolytic Forced Degradation Study of Pharmaceuticals. Current Microwave Chemistry, 4(2), 152-157.
Nüchter, M., Ondruschka, B., Bonrath, W., & Gum, A. (2004). Microwave assisted synthesis – a critical technology overview. Green Chem., 6(3), 128–141. https://doi.org/10.1039/B310502D
Razzaq, T., & Kappe, C. O. (2007). Rapid preparation of pyranoquinolines using microwave dielectric heating in combination with fractional product distillation. Tetrahedron Letters, 48(14), 2513–2517. https://doi.org/10.1016/j.tetlet.2007.02.052
Abdelwahab, N. S., Hassan, H. M., & Magd, A. M. A. (2020). Rapid microwave-assisted hydrolytic degradation of colchicine: In silico ADME/Tox profile, molecular docking, and development of innovative RP-Chromatographic methods. Microchemical Journal, 152, 104419. https://doi.org/10.1016/j.microc.2019.104419
Bende, G., Kollipara, S., Kolachina, V., & Saha, R. (2007). Development and Validation of an Stability Indicating RP-LC Method for Determination of Imatinib Mesylate. Chromatographia, 66(11–12), 859–866. https://doi.org/10.1365/s10337-007-0415-3
Madhavi, A., Reddy, G. S., Suryanarayana, M. V., & Naidu, A. (2008). Development and Validation of a New Analytical Method for the Determination of Related Components in Tolterodine Tartarate Using LC. Chromatographia, 68(5–6), 399–407. https://doi.org/10.1365/s10337-008-0735-y
Prekodravac, B., Damm, M., & Kappe, C. O. (2011). Microwave-assisted forced degradation using high-throughput microtiter platforms. Journal of Pharmaceutical and Biomedical Analysis, 56(5), 867–873. https://doi.org/10.1016/j.jpba.2011.07.042
Da Silva FE, Kaefer CL, Becker N, Barbosa S, Picolotto RS, Barin JS, Flores ÉM. (2013). Innovative use of microwave radiation in forced degradation of azol pharmaceutical. Rev Bras Farm., 94, 265-272.
Sonawane, S. (2011). Optimization of Forced Degradation Using Experimental Design and Development of a Stability-Indicating Liquid Chromatographic Assay Method for Rebamipide in Bulk and Tablet Dosage Form. Scientia Pharmaceutica, 79(1), 85–96. https://doi.org/10.3797/scipharm.1011-06
Sonawane, S., & Gide, P. (2013). Study on approaches to expedite and simplify forced degradation of eplerenone. Journal of Liquid Chromatography & Related Technologies, 36(15), 2156–2165. https://doi.org/10.1080/10826076.2012.717054
Prajapati DK, Dave JB, Patel CN. (2015). Microwave assisted comparative forced degradation study of oral Cephalosporin drugs using quality by design (QbD) approach and stability indicating RP-HPLC analysis. World J Pharm Pharmaceut Sci., 4, 1714-1727.
Patel, P., & Mehta, P. (2017). Microwave-assisted heating: Innovative use in hydrolytic forced degradation of selected drugs. Journal of Microwave Power and Electromagnetic Energy, 51(3), 205–220. https://doi.org/10.1080/08327823.2017.1354746
Blessy, M., Patel, R. D., Prajapati, P. N., & Agrawal, Y. K. (2014). Development of forced degradation and stability indicating studies of drugs—A review. Journal of Pharmaceutical Analysis, 4(3), 159–165. https://doi.org/10.1016/j.jpha.2013.09.003
Reynolds DW, Facchine KL, Mullaney JF, Alsante KM, Hatajik TD, Motto MG. (2002). Conducting forced degradation studies. Pharmaceutical Technology, 48-56.
Ngwa G. (2010). Forced degradation as an integral part of HPLC stability-indicating method development. Drug Delivery Technology, 10(5), 56-59.
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