Study of Trace Elements Selenium, Copper, Zinc and Manganese Level in Polycystic Ovary Syndrome (PCOS)

Authors

  • Amel H Mohmmed Department of Chemistry, University of Basrah, College of Science, IRAQ
  • Nadhum A Awad Department of Chemistry, University of Basrah, College of Science, IRAQ
  • Adnan J M AL-Fartosy Department of Chemistry, University of Basrah, College of Science, IRAQ

Keywords:

Selenium, Copper, Zinc and Manganese, PCOS, Immune Function, Thyroid Function

Abstract

Polycystic ovary syndrome (PCOS) is a common endocrine disorder in premenopausal women, trace elements play an important role in PCOS, selenium performs various biological functions such as defense against oxidative stress, immune function and thyroid function, polycystic ovary syndrome (PCOS) is a common endocrine disorder in premenopausal women, trace Elements have important role in PCOS, selenium is involved in many biological functions, such as, protection against oxidative stress, immune function and thyroid function, Copper, zinc and manganese are essential micronutrients that have been integrated into various proteins and metalloenzymes and are active in the metabolic process of cells and in oxidative stress pathways that can lead to oxidative stress.

One hundred and twenty-four of patients' women with poly cystic ovarian syndrome (PCOS) patients and 56 normal ovulatory women participated in the study. Seleniumand serum Copper, zinc and manganese were measured by using flame atomic absorption spectrometry (FAAS).

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References

Raghad Al-Saab and Shaden Haddad. (2014). Detection of thyroid autoimmunity markers in euthyroid women with polycystic ovary syndrome: A case-control study from syria. Int J Endocrinol Metab., 12(3), e17954.

Richard S. Legro, M.D. (2012). Obesity and PCOS: Implications for diagnosis and treatment. Semin Reprod Med, 30(6), 496–506.

doi: 10.1055/s-0032-1328878

Teede HJ, Meyer C, Hutchison SK, Zoungas S, McGrath BP & Moran LJ. (2010). Endothelial function and insulin resistance in polycystic ovary syndrome: the effects of medical therapy. Fertil Steril, 93(1), 184-91.

doi: 10.1016/j.fertnstert.2008.09.034

Majid Bani Mohammad and Abbas Majdi Seghinsara. (2017). Polycystic ovary syndrome (PCOS), diagnostic criteria, and AMH. Asian Pacific journal of cancer prevention: APJCP, 18(1), 17-21.

Chen X, Yang D, Li L, Feng S & Wang L. (2006). Abnormal glucose tolerance in Chinese women with polycystic ovary syndrome. Hum Reprod, 21(8), 2027-2032.

BM Sartor and RP Dickey. (2005). Polycystic ovarian syndrome and the metabolic syndrome. The American Journal of the Medical Sciences, 330(6), 336-342.

doi: 10.1097/00000441-200512000-00012

Weerakiet S, Srisombut C, Bunnag P, Sangtong S, Chuangsoongnoen N, Rojanasakul A. (2001). Prevalence of type 2 diabetes mellitus and impaired glucose tolerance in Asian women with polycystic ovary syndrome. Int J Gynaecol Obstet.,75(2), 177-184.

Mehri Jamilian, Maryam Maktabi & Zatollah Asemi, (2017), A trial on the effects of magnesium-zinc-calcium-vitamin d co-supplementation on glycemic control and markers of cardio-metabolic risk in women with polycystic ovary syndrome. Arch Iran Med., 20(10), 640 – 645.

Mohammed Abbas Taher and Sarah Hashim Mhaibes. (2017). Assessment of some trace elements in obese and non-obese polycystic ovary syndrome (PCOS). International Journal of Science and Research, 6(9), 1333-1341.

Ciftci TU, Ciftci B, Yis O, Guney Y, Bilgihan A & Ogretensoy M.. (2003). Changes in serum selenium, copper, zinc levels and cu/zn ratio in patients with pulmonary tuberculosis during therapy. Biol Trace Elem Res., 95(1), 65-71.

González F, Rote NS, Minium J & Kirwan JP. (2006). Reactive oxygen species-induced oxidative stress in the development of insulin resistance and hyperandrogenism in polycystic ovary syndrome. J Clin Endocrinol Metab. , 91(1), 336-40.

Kelly CC, Lyall H, Petrie JR, Gould GW, Connell JM & Sattar N. (2001). Low grade chronic inflammation in women with polycystic ovarian syndrome. J Clin Endocrinol Metab., 86(6), 2453-2455.

Papp LV, Lu J, Holmgren A & Khanna KK. (2007). From selenium to selenoproteins: synthesis, identity, and their role in human health. Antioxid Redox Signal, 9(7), 775-806.

Rayman MP. (2000). The importance of selenium to human health. Lancet, 356(9225), 233-241.

Lippman SM, Goodman PJ, Klein EA, Parnes HL, Thompson IM Jr, Kristal AR, Santella RM, Probstfield JL, Moinpour CM, Albanes D, Taylor PR, Minasian LM, Hoque A, Thomas SM, Crowley JJ, Gaziano JM, Stanford JL, Cook ED, Fleshner NE, Lieber MM, Walther PJ, Khuri FR, Karp DD, Schwartz GG, Ford LG & Coltman CA Jr. (2005). Designing the Selenium and Vitamin E Cancer Prevention Trial (SELECT). J Natl Cancer Inst., 97(2), 94-102.

Salama Alaa, Sakr Yasser & Reinhart Konrad. (2007). The role of selenium in critical illness: Basic science and clinical implications. Indian Journal of Critical Care Medicine, 11(3), 127-138.

Milal M. Al-Jeborry. (2017). Some Altered Trace Elements in Patients with Polycystic Ovary Syndrome. British Journal of Medicine & Medical Research, 20(3), 1-10.

Atheer Awad Mehde. (2014). Study of several biochemical features in sera of patients with polycystic ovaries and compared with the control group. Australian Journal of Basic and Applied Sciences, 8(10), 620-627.

Kauffman RP, Tullar PE, Nipp RD & Castracane VD. (2011). Serum magnesium concentrations and metabolic variables in polycystic ovary syndrome. Acta Obstet Gynecol Scand., 90(5), 452-458.

doi: 10.1111/j.1600-0412.2010.01067

Barbagallo M, Dominguez LJ, Galioto A, Ferlisi A, Cani C, Malfa L, Pineo A, Busardo' A & Paolisso G. (2003). Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X. Mol Aspects Med., 24(1-3), 39-52.

Y. P. Mamza, Z. B. Abdullahi, R. M. Gali, DS Mshelia, R. Y. Genesis & S. A. Habu. (2016). Status of Serum Zinc and Magnesium among Type 2 Diabetic Subjects in Maiduguri. IOSR Journal of Dental and Medical Sciences, 15(7), 66-70.

Fatemeh Pourteymour Fard Tabrizi, Mahzad Mehrzad Sadaghiani, Beitollah Alipoor & Alireza Ostadrahimi. (2013). Minerals status in women with polycystic ovary syndrome. Feyz Journals of Kashan University of Medical Sciences, 16(7).

Lindsay TJ and Vitrikas KR. (2015). Evaluation and treatment of infertility. Am Fam Physician, 91(5), 308-314.

Dicken Weatherby and Scott Ferguson. (2004). Blood chemistry and CBC analysis, In: Clinical Laboratory Testiing from a Funtional Perspectiv, (1st ed.) United Kingdom: Weatherby & Associates, LLC.

Ji X and Ren J. (2002). Determination of copper and zinc in serum by derivative atomic absorption spectrometry using the microsampling technique. Analyst, 127(3), 416-419.

Baydas B, Karagoz S & Meral I. (2002). Effects of oral zinc and magnesium supplementation on serum thyroid hormone and lipid levels in experimentally induced diabetic rats. Biol Trace Elem Res., 88(3), 247-253.

Marczenko z, (1979). Spectrophotometric Determination of Elements. Ellis Horwood Ltd, ENGLAND.

Available at:

https://shodhganga.inflibnet.ac.in/bitstream/10603/71019/10/10_chapter%204.pdf

Adnan J. M. Al-Fartosy and Ibrahim M. Mohammed. (2017). Comparison of insulin resistance, prolactin and hba1c with relation to obesity in men and women of healthy control and diabetic patients / meisan-IRAQ. International Journal of Current Research, 9(8), 55643-55648.

Available at:

https://www.journalcra.com/sites/default/files/issue-pdf/25092.pdf

Pieczyńska J and Grajeta H. (2015). The role of selenium in human conception and pregnancy. J Trace Elem Med Biol., 29, 31-38.

doi: 10.1016/j.jtemb.2014.07.003.

Chen, P., Totten, M., Zhang, Z., Bucinca, H., Erikson, K., Santamaría, A., Bowman, A. B. & Aschner, M. (2019). Iron and manganese-related CNS toxicity: mechanisms, diagnosis and treatment. Expert Review of Neurotherapeutics. 19(3), 243-260.

Sharif ME, Adam I, Ahmed MA, Rayis DA & Hamdan HZ. (2017). Serum Level of Zinc and Copper in Sudanese Women with Polycystic Ovarian Syndrome. Biol Trace Elem Res., 180(1), 23-27.

doi: 10.1007/s12011-017-1000-8

Morteza Azhdarzadeh, Maryam Noroozian, Haniyeh Aghaverdi, Seyed Mostafa Akbari, Larry Baum & Morteza Mahmoudi. (2013). Serum multivalent cationic pattern: speculation on the efficient approach for detection of alzheimer's disease. Scientific Reports, 3(1), 2782.

doi: 10.1038/srep02782.

Malavolta M, Piacenza F, Basso A, Giacconi R, Costarelli L & Mocchegiani E. (2015). Serum copper to zinc ratio: Relationship with aging and health status. Mech Ageing Dev., 151, 93-100.

doi: 10.1016/j.mad.2015.01.004

Hussien, K.A., Al-Salih, R.M., & Ali, S.A. (2017). Evaluation of hormones and trace elements in women with unexplained infertility. Thi-Qar University, 14(2), 94-108.

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Published

2019-11-30

How to Cite

Amel H Mohmmed, Nadhum A Awad, & Adnan J M AL-Fartosy. (2019). Study of Trace Elements Selenium, Copper, Zinc and Manganese Level in Polycystic Ovary Syndrome (PCOS). International Journal for Research in Applied Sciences and Biotechnology, 6(6), 16–22. Retrieved from https://ijrasb.com/index.php/ijrasb/article/view/271