Iron, Ferritin and Hepcidin Levels in Patients with Iron Deficiency Anemia

Authors

  • Rabaa Khaled Abdel Salam Department of Life Sciences, College of Science, Tikrit University, IRAQ.
  • Saria Naji Mohsin Department of Life Sciences, College of Science, Tikrit University, IRAQ.

Keywords:

iron deficiency anemia, hepcidin, ferritin, iron

Abstract

This study was conducted to identify the role of some blood parameters, levels of some hormones, proteins, and cellular kinetics that have a role in iron transport and storage, in addition to their relationship with each other and with blood and sex parameters for patients with severe and moderate iron deficiency anemia, and to compare the parameters with healthy people. The study period lasted for the period from (December 2020 until March 2021) The presence of iron deficiency anemia was confirmed by examining the blood picture and the criteria of hepcidin and ferritin. The results showed a significant decrease in the in the concentration of hepcidin, ferritin and iron in patients compared to the control group.

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References

Mohamed, M. S. A. (2019). Evaluation of Plasma Interleukin-10 Level in Sudanese Iron Deficiency Anemia Patients among Khartoum State (Doctoral dissertation, Sudan University of Science and Technology).

Harper, J.L., Marcel, E.C. and Emmanuel, C.B., (2015). Iron Deficiency Anemia: Practice essentials, Pathophysiology and Etiology. Medscape.

Nemeth, E.; Tuttle, M.S.; Powelson, J.; Vaughn, M.B.; Donovan, A.; Ward, D.M.; Ganz, T.; and Kaplan, J. (2004). Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science, 306, 2090–2093.

Camaschella, C. (2013). Iron and hepcidin: a story of recycling and balance. Hematology, American Society of Hematology, Education Program, 2013:1-8.

Mastrogiannaki, M., Matak, P. and Peyssonnaux, C. (2013). The gut in iron homeostasis: role of HIF-2 under normal and pathological conditions. Blood,122(6):885-892.

M. Daugirdas, J.T. (2017). Iron and anemia in chronic kidney disease: New treatments changing old paradig. Hemodialysis, 21(1):3-5. Schwatz, A.B.; Prasad, V. and Garcha, J. (2004). Anemia of chronic kidney disease: a combined effect of marginal iron stroes and erythropoietin deficiency. Dis. Trans., 33(12): 758 – 767.

Schwatz, A.B.; Prasad, V. and Garcha, J. (2004). Anemia of chronic kidney disease: a combined effect of marginal iron stroes and erythropoietin deficiency. Dis. Trans., 33(12): 758 – 767.

Knovich, M. A., Storey, J. A., Coffman, L. G., Torti, S. V., & Torti, F. M. (2009). Ferritin for the clinician. Blood reviews, 23(3), 95-104

Hoffbrand, A.V.; Pettit, J.E. and Moss, P.A. (2001). Essential hematology. 4th ed. Blackwell Science Ltd.

Mahajan, G., Sharma, S., Chandra, J., & Nangia, A. (2017). Hepcidin and iron parameters in children with anemia of chronic disease and iron deficiency anemia. Blood research, 52(3), 212-217.

Basu, S., Kumar, N., Srivastava, R., & Kumar, A. (2016). Maternal and cord blood hepcidin concentrations in severe iron deficiency.

Maliken, B. D., Nelson, J. E., & Kowdley, K. V. (2011). The hepcidin circuits act: balancing iron and inflammation. Hepatology, 53(5), 1764-1766

Yang, C., He, L., He, P., Liu, Y., Wang, W., He, Y., . . . Gao, F. (2015). Increased drug resistance in breast cancer by tumor-associated macrophages through IL-10/STAT3/bcl-2 signaling pathway. Medical oncology, 32(2), 14

Huang, P., Wang, J., Lin, X., Yang, F.F., Tan, J.H. (2017). Effects of IL-10 on iron metabolism in LPS-induced inflammatory mice via modulating hepcidin expression. European Review of Medicine and Pharmacological Sciences, 21(15):3469-34

Terefe, B., Birhanu, A., Nigussie, P., & Tsegaye, A. (2015). Effect of maternal iron deficiency anemia on the iron store of newborns in Ethiopia. Anemia, 2015.

Shin, D. H., Kim, H. S., Park, M. J., Suh, I. B., & Shin, K. S. (2015). Utility of access soluble transferrin receptor (sTfR) and sTfR/log ferritin index in diagnosing iron deficiency anemia. Annals of Clinical & Laboratory Science, 45(4), 396-402.

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Published

2021-09-30

How to Cite

Rabaa Khaled Abdel Salam, & Saria Naji Mohsin. (2021). Iron, Ferritin and Hepcidin Levels in Patients with Iron Deficiency Anemia. International Journal for Research in Applied Sciences and Biotechnology, 8(5), 137–139. Retrieved from https://ijrasb.com/index.php/ijrasb/article/view/233