Evaluation of the Relationship between the Level of DHEA-S and Sex Hormones in Some Infertile Iraqi Men
Keywords:
Male Infertility, DHEA-S, Sex hormonesAbstract
This study aims to evaluate serum levels of the Dehydroepiandrosterone sulfate (DHEA-S) and its relationship with some sex hormones such as Follicle stimulating hormone (FSH), Luteinizing hormone (LH), prolactin and testosterone hormone and the infertility type in some infertile Iraqi men.
Blood and seminal fluid samples from (60) idiopathic male infertile and (60) healthful individuals as a control group aged (18 to 60 year) were collected from private clinics. Serum hormones (DHEA-S, FSH, LH, prolactin and testosterone) were measurement using Enzyme Linked Immunosorbent Assay (ELISA).
The levels of DHEA-S, FSH, LH and prolactin are significantly higher (P≤0.01) expect of the testosterone level was significantly decreased (P≤ 0.01) in the infertile men as compared with control group. High significant differences (P≤0.01) were recorded when comparing the hormonal levels (DHEA-S, FSH, LH, prolactin and testosterone) according to the age groups. There are significant differences (P≤ 0.01) in levels of (DHEA-S, FSH, LH, prolactin and testosterone) in the infertility period. Smoker infertile men have high levels (P≤ 0.05) in the DHEA-S and LH while have low levels in the prolactin hormones compared with control. Patients with family history have shown significant differences (P≤0.05) in the levels of DHEA-S, FSH, LH and prolactin.
In conclusion, this study revealed significantly increase in the DHEA-S levels in the infertile men and negative correlation between DHEA-S and FSH. Therefore, DHEA-S has important role in the diagnosis and follow up of the male infertility.
Downloads
References
Turek, PJ (2008) Male infertility. In: Tanagho EA, Mc Aninch JW (Eds.), (17th edn) Smith’s general urology, Mc Graw-Hill Companies, New York, USA, pp. 684-717.
Wong WY, Thomas CM, Merkus JM, Zielhuis GA, Steeqeers-Theunissen RP (2000) Male factor sub fertility: Possible causes and the impact of nutritional factors. Fertil Steril 73(3): 435-442.
Sohrabvand F, Jafarabadi M (2005) Knowledge and attitudes of infertile couples about assisted reproductive technology. Int J Repord Biomed 3(2): 90-94.
Abraham,P.A.; Kazman, J.B.; Zeno, S.A.; Poth, M. and Deuster, P.A.(2013).Age –related decline in salivary dehydroepi- androsterone sulfate and associated health risks among African Americans. Ethn Dis.23(2):149-54.
Ross, M and Pawlina, W. (2011). Histology: A Text and Atlas (6th ed.). Lippincott Williams &Wilkins.pp.708,780.
Franchimont, P. 1983. Regulation of gonadal androgen secretion. Horm Res 18:7-17.
Jarow, J., Sigman, M., and Kolettis, P. N. (2010). AUA–Clinical guidelines: the optimal evaluation of the infertile male: best practice statement. AUA–Home. American Urological Association Education and Research, Inc.
Jarow, JP. (2003). Endocrine causes of male infertility. Urol Clin North Am. 30: 83-90.
Goldzieher JW, Dozier TS and Smith KD. (1976). Improving the diagnostic reliability of rapidly fluctuating plasma hormone levels by optimized multiple-sampling techniques. J Clin Endocrinol Metab; 43:824.
Hameed S, Jayasena CN, Dhillo WS. (2011). Kisspeptin and fertility. J Endocrinol. 208:97-105.
Singh R., H Alaa and Agarwal A. (2011). Thyroid Hormones in Male Reproduction and Fertility Rajender. The Open Reproductive Science Journal, 3, 98-104.
Sigman, M. and Jarrow, JP. (2007). "Current Management of Male Infertility, An Issue of Urologic, E-Book". Saunders Elsevier. ed.10th; p. 609-53, 6.
Masud, S; Mehboob, F; and Bappi MU; (2007). "Severe hyperprolactinemia directly depresses the gonadal activity causing infertility". Esculapio J Services Inst Med Sci. 2:25–7.
Maria, M.; (2016). The Role of Prolactin in Men. Endocrinol Metab Syndr. 5: 222.
Al-Rawi, K, M. (2000). An introduction to statistics. Second Edition. House of Books for Printing and Publishing - University of Mosul.
Zalata, A. A. et al. (2008) ‘Follicle‐stimulating hormone receptor polymorphism and seminal anti‐Müllerian hormone in fertile and infertile men’, Andrologia. Wiley Online Library, 40(6), pp. 392–397.
Safarinejad, M. R., Shafiei, N. and Safarinejad, S. (2011) ‘Evaluating the role of the FSH receptor gene Thr307‐Ala and Asn680‐Ser polymorphisms in male infertility and their association with semen quality and reproductive hormones’, Bju International. Wiley Online Library, 108(2b), pp. E117–E125.
Al-Nahi, A. S. (2015) ‘Evaluation of FSH, LH, Testosterone, Prolactine, TSH and T4 hormones levels in different subgroups of infertile males.’, Al-Kufa University Journal for Biology. University of Kufa, 7(3), pp. 47–54.
Phillips GB, Relationship between serum dehydroepiandrosterone sulfate, androstenedione, and sex hormones in men and women. European journal of endocrinology. 1996; 134 (2): 201-6.
Al-Siddeig, M. and Ismail, A. (2016). Serum Testosterone and Dehydroepiandrosterone-Sulfate (DHEA-S) Level among Oligospermia and Azoospermia Patients. Volume 15, Issue 4; PP 62-65.
Garcia Diez, LC, Gonzalez Buitrago JM, Corrales JJ, Battaner E, Mirales JM. Hormone level in serum and seminal plasma of men with different type of azoospermia. J Reprod Fertile 1983; 67: 209-14.
Ramesh, Babu S., Sadhnani M.D., Swarna M., Padmavathi P. and Reddy P.P. (2004). Evaluation of FSH, LH and testosterone levels in different subgroups of infertile males. Indian Journal of Clinical Biochemistry, 19 (1) 45-49.
Lalitha c, Sayee R, Jeyanthi K, Shubha R. Hormonal factors associated with hypogonadism and infertility in males – chromosomal abnormality. IOSR Journal of Dental and Medical Sciences. 2013; 10 (1): 71-75.
Masanori Yamamoto, Satoshi Katsuno, Keisuke Yokoi, Hatsuki Hiei, and Koji Miyake, Serum inhibin levels in normal men and men with idiopathic infertility. Nagoya J. Med. Sci. 1995; 58: 35-39.
Mossa, H. A. L. (2010) ‘The Effect of Seasonal, Age, Smoking and Occupational exposure status on semen parameters in Iraqi Subjects’, Al-Mustansiriyah Journal of Science. Al-Mustansyriah University, 21(7), pp. 12–18.
Khadhim, M. M., Al-quizwini, T. S. and Hussian, T. A. (2015) ‘The Role of Protamine 1 Gene Polymorphism and Anti FSH Antibody in Infertile Couples’, Al-Qadisiyah Medical Journal, 11(20), pp. 85–91.
Al-Haija, R. W. M. A. (2011) ‘Main causes of infertility among men treated at Razan Centers in West Bank: Retrospective study’.
Moghadam, M. H. B. et al. (2011) ‘Evaluation of the general health of the infertile couples’, Iranian journal of reproductive medicine. Shahid Sadoughi University of Medical Sciences and Health Services, 9(4), p. 309.
Omran, H. M., Bakhiet, M. and Dashti, M. G. (2013) ‘Evaluation of age effects on semen parameters of infertile males’, Andrology, 2(106), pp. 250–2167.
Raman, J. D. and Schlegel, P. N. (2002) ‘Aromatase inhibitors for male infertility’, The Journal of urology. Wolters Kluwer Philadelphia, PA, 167(2 Part 1), pp. 624–629.
Leowattana, W. (2004). DHEAS as a new diagnostic tool. Clinica Chimica Acta; International Journal of Clinical Chemistry, 341, 1–15.
Boeri, L., Capogrosso, P., Ventimiglia, E., Pederzoli, F., Cazzaniga, W., Chierigo, F., et al. (2019). Heavy cigarette smoking and alcohol consumption are associated with impaired sperm parameters in primary infertile men. Asian J. Androl. 21, 478–485. doi: 10.4103/aja.aja_110_18.
Rehman R, Zahid N, Amjad S, Baig M and Gazzaz ZJ (2019) Relationship Between Smoking Habit and Sperm Parameters Among Patients Attending an Infertility Clinic. Front. Physiol. 10:1356.
Wallach, E. E., Hughes, E. G. and Brennan, B. G. (1996) ‘Does cigarette smoking impair natural or assisted fecundity?’, Fertility and sterility. Elsevier, 66(5), pp. 679–689.
Weisberg, E. (1985) ‘Smoking and reproductive health.’, Clinical reproduction and fertility, 3(3), p. 175.
Ochedalski, T. et al. (1994) ‘Examining the effects of tobacco smoking on levels of certain hormones in serum of young men’, Ginekologia polska, 65(2), pp. 87–93.
Dai, JB, Wang ZX. and Qiao ZD. (2015). The hazardous effects of tobacco smoking on male fertility. Asian J Androl. 17(6):954–60.
Gandhi, J., Hernandez, R. J., Chen, A., Smith, N. L., Sheynkin, Y. R., Joshi, G., et al. (2017). Impaired hypothalamic-pituitary-testicular axis activity, spermatogenesis, and sperm function promote infertility in males with lead poisoning. Zygote 25, 103–110.
Babu, S. R. et al. (2004) ‘Evaluation of FSH, LH and testosterone levels in different subgroups of infertile males’, Indian Journal of Clinical Biochemistry. Springer, 19(1), pp. 45–49.
Jawad, E. S., Mubark, H. R. and Odah, T. K. (2019) ‘The Relationship Between The Genotypes Frequency For The PRM1 Gene And Some Of Risk Factors In Male Infertile Of Thi Qar Province’, Journal of Education for Pure Science. Thi-Qar University, 9(1), pp. 102–112.
Ismael, Z.K, M.O. Selman, H.A.L. Mossa and L.A. AL-Anbari (2017). Relationship of FSH, LH, DHEA and Testosterone Levels in Seminal Plasma with Sperm Function Parameters in Infertile Men. Merit Research Journal of Medicine and Medical Sciences, 5(12): 627-634.
Cannarella, R.; Condorelli, R.; Dall’Oglio, F.; Vignera, S.; Laura M. Mongio, L.; Micali, G.; and Calogero, A. (2020). Increased DHEAS and Decreased Total Testosterone Serum Levels in a Subset of Men with Early-Onset Androgenetic Alopecia: Does a Male PCOS-Equivalent Exist?. International Journal of Endocrinology. Volume 2020. P 8.
Charlton, M., Angulo, P., Chalasani, N., Merriman, R., Viker, K., Charatcharoenwitthaya, P., Sanderson, S., Gawrieh, S., Krishnan and A., Lindor, K. Low circulating levels of dehydroepiandrosterone in histologically advanced nonalcoholic fatty liver disease. Hepatology. 2008; 47:484–492.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
editor@ijrasb.com 