Article Review: Coloration Biochemistry and Molecular Biology Between Polycystic Ovary Syndrome and Diabetes Mellitus Type 2
Keywords:
T2DM, PCOS, Genes, Type 2 DiabetesAbstract
Polycystic ovarian syndrome is the most common reproductive endocrine disorder in premenopausal women Given the clinical overlap between PCOS and type 2 diabetes mellitus (T2DM), this research sought to investigate if genes associated with T2DM were similarly connected to PCOS vulnerability. In either the univariate or multivariate scenario, none of the 16 SNPs was significantly associated with Polycystic Ovarian Syndrome after Bonferroni correction for multiple testing. The nine T2DM genes investigated in this preliminary research may not be the main PCOS risk factors in Indian women. Our findings add to the absence of evidence of a link between T2DM genes and PCOS in Chinese and Caucasians, suggesting that this trend may be universal. To determine the exact significance of the diabetes genes, researchers will need to conduct extensive studies that involve women with T2DM and PCOS.
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