A Review on Understanding the Connecting link between Genes and Cancer and the Involvement of Genetics in Cancer Development
Keywords:
cancer, cancer genes, tumor cell growth, apoptosis, neoplastic cell, tumor evolution, cancer geneticistsAbstract
Cancer genetics is the scientific discipline that investigates the genes and pathways that drive the development of cancer. Cancer geneticists use several approaches including the analysis of the genomes of cancer patients, and that of their tumors, to identify cancer genes. These studies are performed along with experiments in in vitro and in vivo models to decipher the mechanisms that drive tumorigenesis. Cancer geneticists aim to identify cancer genes, that when mutated, contribute towards cancer development by promoting tumor cell growth and by conferring upon a neoplastic cell the ability to evade the cell cycle and apoptosis checkpoints that might normally control their growth. Cancer geneticists are also interested in the networks and pathways that contribute to tumor development and the way cancer genes work together to market tumor evolution.
Downloads
References
Genetics in Prevention and Treatment of Cancer by World Health Organization. https://www.who.int/genomics/about/Cancer.pdf
Lach, R. P., & Adams, D. J. (2013). Cancer Genetics. Brenner’s Encyclopedia of Genetics, 416–419. doi:10.1016/b978-0-12-374984-0.00190-X
Douglas W. Green, Jeffrey A. Drebin, in Surgical Research, 2001.
Genetic Testing for Cancer Risk by Cancer.Net. https://www.cancer.net/navigating-cancer-care/cancer- basics/genetics/genetics-cancer
Molecular Tools in Cancer Research. Mauro W. Costa, Nadia Rosenthal, in Abeloff's Clinical Oncology (Fifth Edition), 2014
Antoniou AC et al. A comprehensive model for familial breast cancer incorporating BRCA1, BRCA2, and other genes. British Journal of Cancer. 2002. 86(1): 76-83.
Bosch FX, de Sanjose S. Chapter 1: Human papillomavirus and cervical cancer—burden and assessment of casualty. J Natl Cancer inst Monogr. 2003, 31: 3-13.
Hinds, P. W., & Weinberg, R. A. (1994). Tumor suppressor genes. Current Opinion in Genetics & Development, 4(1), 135–141. doi:10.1016/0959-437x(94)90102-3
Todd R, Wong DT Anticancer Research, 01 Nov 1999, 19(6A):4729-4746; PMID: 10697588
The promise of cancer genetics by Dr Daniel A Haber, MD Eric R Fearon, MD Published: May, 1998 DOI: https://doi.org/10.1016/S0140-6736(98)90326-9
Introduction to Cancer Genetics. NHS Greater Glasgow and Clyde; https://www.nhsggc.org.uk/about- us/professional-support-sites/west-of-scotland-genetic-services/cancer-genetics/introduction-to-cancer- genetics/#
The Genetics of cancer by National Cancer Institute (NIC) https://www.cancer.gov/about-cancer/causes- prevention/genetics
Understanding Genetic Testing for Cancer, American Cancer Society https://www.cancer.org/cancer/cancer- causes/genetics.html
Genetic Testing for Inherited Cancer Susceptibility Syndromes; https://www.cancer.gov/about-cancer/causes- prevention/genetics/genetic-testing-fact-sheet
Genetic Testing for Cancer: What to Know; https://www.healthline.com/health/genetic-testing-for-cancer#ideal- candidates
Henry T. Lynch, C. Richard Boland, in Goldman's Cecil Medicine (Twenty Fourth Edition), 2012
Knudson, A. G. (2002). Cancer genetics. American Journal of Medical Genetics, 111(1), 96– 102. doi:10.1002/ajmg.10320
Genetics; Jennifer E. Axilbund, Amy L. Gross and Kala Visvanathan in Early Diagnosis and Treatment of Cancer Series: Breast Cancer, 2011
Cancer Genetic Screening and Ethical Considerations for Precision Medicine ; R.G. Dumitrescu, in Progress and Challenges in Precision Medicine, 2017
Prevention and genetic testing for breast cancer: variations in medical decisions ; Louise Bouchard 1, I Blancquaert, F Eisinger, W D Foulkes, G Evans, H Sobol, C Julian-Reynier 2004 Mar;58(6):1085-96. doi: 10.1016/s0277-9536(03)00263-6.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
editor@ijrasb.com 